Differential Proteomic Analysis of Endometriosis in Mouse

Based on the established endometriosis BALB/c mice model,the differential expression of eutopic endomereium proteins from the normal and endometriosis mice were compared by two-dimensional electrophoresis.There are 61 spots of significant differential proteins to be found.Among them,23 protein-spots were identified by mass spectrometry.They were 11 kinds of regulation-related proteins,4 kinds of signal transduction-related proteins,1 kind of metabolism-related proteins,5 kinds of membrane associated proteins,1 kinds of cyskeletal proteins and 1 kinds of RNA helicase enzymes,respectively.The application of proteomics in EMs research would be important for the study of the mechanism and should be significant in the diagnosis and treatment of the disease.The results would provide a theory foundation for studying the pathogenesis of endometriosis and some academic thereunder for searching early diagnosis marker and therapeutic target.