Endometriosis as a risk factor for Ovarian or Endometrial Cancer – Results of a hospital based case control study

This hospital-based case-control study assessed whether endometriosis is associated with ovarian or endometrial cancer, using 289 cancer cases (endometrial or ovarian cancer) and 1016 population controls recruited via newspaper advertisement. Logistic regression models evaluated predictors including age, number of pregnancies, previous oral contraceptive use, and additionally whether participants had been diagnosed with endometriosis, with model comparison by likelihood ratio tests. Endometriosis was more frequent among cases than controls (4.8% vs 2.1%), and endometriosis was associated with case-control status (OR = 2.53, 95% CI 1.23–5.21), while previous oral contraceptive use was inversely associated (OR = 0.41, 95% CI 0.30–0.55). This paper is centrally about endometriosis — it tests endometriosis as a risk factor for endometrial or ovarian cancer and reports its effect in a case-control prediction context.

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