Bioinformatics analysis of the clinical value and potential mechanisms of CBS/H2S in Glioma through 1027 samples.

Yuanyuan Si, Ningjia Song, YONG JI
2024 · doi:10.21203/rs.3.rs-3942047/v1
preprint OA: closed CC-BY-4.0
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Abstract

Background: Glioma is a highly malignant brain tumor with dismal prognosis, limiting effective treatment strategies. Thus,identifying the molecular mechanisms underlying tumor-related gene in glioma is critical. Cystathionine beta-synthase (CBS), a key kinase in the brain responsible for producing hydrogen sulfide (H2S) internally, has been implicated in the progression of malignant tumors. However, there is a paucity of studies focusing on CBS/H2S in the context of glioma. Methods Data analysis of mRNA-seq level was performed in a group of 325 patients with glioma from the Chinese Glioma Genome Altas (CGGA) database and 702 patients from The Cancer Genome Altas (TCGA). The TISIDB database was employed to explore the connection between CBS expression and immune cell infiltration levels.Furthermore, the variation in CBS expression across multiple cancer types were examined by GEPIA database and TISIDB database. Results CBS showed enrichment in low-grade gliomas and IDH-mutant gliomas. Furthermore,CBS held great promise as a biomarker for glioblastoma and an independent prognostic determinant affecting patients’ overall survival. Notably,the analysis of immune infiltration revealed inverse associations between CBS and 28 distinct types of tumor-infiltrating lymphocytes (TILs).Moreover,CBS played a pivotal role in Pan-cancer,highlighting its significance in Pan-cancer studies.

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License: CC-BY-4.0