Cancer survivors present physical and psychological sequelae after COVID-19 hospitalization: a prospective and longitudinal cross-sectional study assessing post-acute sequelae of SARS-CoV-2 infection (PASC) in cancer patients

Victor Figueiredo Leite, Maria Teresa Duarte Pereira da Cruz Lourenço, Christina Haas Tarabay, Agnes Ayumi Sewo Mori, Giseli Maria Neto, Thais Manfrinato Miola, Luciana da Costa, Celena Freire Friedrich, Telma Ribeiro Rodrigues, Jordana Balbinot, Elisabete Carrara Angelis
2022 · doi:10.21203/rs.3.rs-1994417/v1
preprint OA: gold CC-BY-4.0
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Abstract

Purpose: to prospectively assess symptoms and impairments following COVID-19 hospitalization in a cancer population, particularly regarding fatigue, nutritional status, speech and swallowing, anxiety, depression, and post-traumatic stress disorder (PTSD). Methods: Prospective and longitudinal cross-sectional study with cancer survivors hospitalized due to COVID-19 from June to December 2020. Participants were assessed at discharge, and after one, three, six and twelve months. Results: We included 51 participants. At the time of discharge, 84.3% participants presented at least one impairment: fatigue (68.6%), anxious/depressive symptoms (23.5%), voice and speech impairments (19.6%), dysphagia (21.6%), and were at nutritional risk (54.9%). After one year, impairments were present in 53.7% of the sample: fatigue (34.2%), anxious/depressive symptoms (39.2%), voice and speech impairments (29.4%), dysphagia (33.3%). No participants presented nutritional risk after one year. Participants had no significant impact on their activities of daily living (ADL). Conclusion: Cancer survivors hospitalized due to COVID-19 in our institution presented high levels of fatigue, nutritional risk, anxious/depressive and PTSD symptoms at the time of discharge, with improvement of fatigue, and some aggravation of speech, swallowing and psychological symptoms in the following year.

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License: CC-BY-4.0