Impact of Fat Mass and Fat-Free Mass on Locomotive Syndrome and Frailty in an Elderly Japanese Population: A Comprehensive Analysis

Hiroaki Nakashima, Sadayuki Ito, Naoki Segi, Jun Ouchida, Ippei Yamauchi, Satoshi Tanaka, Yasuhiko Takegami, Shinya Ishizuk, Yukiharu Hasegawa, Shiro Imagama
2024 · doi:10.21203/rs.3.rs-4927185/v1
preprint OA: closed CC-BY-4.0
📄 Open PDF View at publisher

Abstract

Abstract Background: The roles of fat mass index (FMI) and fat-free mass index (FFMI) in locomotive syndrome (LS) and frailty are not well understood. The current study explored the associations between FMI and FFMI and the prevalence of LS and frailty in an elderly Japanese population. Methods: This study examined 814 participants who underwent health checkups. Body composition including FMI, FFMI, and bone mineral content was measured via bioelectrical impedance analysis. LS was assessed using the Geriatric Locomotive Function Scale, and frailty was evaluated using the Japanese Cardiovascular Health Study criteria. Logistic regression analysis adjusted for age and sex was also performed. Results: A high FMI was significantly associated with LS, and a low FFMI was significantly associated with frailty. A U-shaped association was observed between FMI and frailty. Hence, both low and high FMI were associated with increased frailty risk. Participants diagnosed with both LS and frailty had a higher FMI and lower FFMI than those diagnosed with only one of the two conditions. Conclusions: FMI and FFMI have distinct roles in LS and frailty among elderly individuals. Monitoring and managing body composition via targeted interventions can improve musculoskeletal health and quality-of-life in aging populations.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

References (25)

Source provenance

crossref
last seen: 2026-06-16T06:25:13.829872+00:00
europepmc
last seen: 2026-05-20T01:45:00.602351+00:00
unpaywall
last seen: 2026-05-22T02:00:06.705733+00:00
License: CC-BY-4.0