Морфологічні особливості та активність естрогенових рецепторів ендометрію та фокусів аденоміозу в пацієнток у постменопаузі

and methods. 30 cases of adenomyosis were investigated in the presence of the hyperplastic processes in the endometrium (endometrial adenocarcinoma of the uterine body and endometrial hyperplasia) and without it (age changes) in patients aged 51-73 years. We conducted immunohistochemical research and hematoxylin and eosin stain. IHC blocks were produced by the method of Tissue Microarray. The expression of estrogen markers was evaluated according to point system of general staining method for ER-status determining. Results. Morphological structure of eu- and ectopic endometrium was studied in the work in detail, according to comorbidity. Moderately differentiated adenocarcinoma (G2) was diagnosed in 4 cases out of 10 in the group with the endometrial adenocarcinoma, and in 6 cases - level 2 of the nuclear atypia. It was revealed that morphological picture of adenomyosis in the presence of hyperplastic processes in the endometrium is characterized by the predominance of glandular component over stromal one in the ectopic endometrium. Significant differences between all the groups of the studied women during the estimation of the levels of the estrogen activity of the components of the eutopical endometrium were not revealed, with the exception of endometrial adenocarcinoma. Comparative analysis of our results with data of the other researchers was conducted. Conclusion. It was established that the foci of adenomyosis retain their activity, that is morphologically manifested as the foci of proliferation and secretion. The level of ER expression of eutopical endometrium dominates over the endometrium of adenomyosis foci in the presence of the endometrial adenocarcinoma and the atrophy of the endometrium. Low level of ER expression in stromal cells in comparison with the glandular was demonstrated both in the foci of endometrial heterotopias and in eutopical endometrium in endometrial carcinoma. Low level of intensity of stromal component expression of the foci of endometrial heterotopias was found in the group with endometrial adenocarcinoma in comparison with the other groups. Further studying of the activity level of progesterone receptors in eutopical endometrium and in the foci of the internal endometriosis is perspective for this category of women.

- Hresko, M. D. (2013) Kharakterystyka hormonalnoho homeostazu v zhinok iz nadmirnymy matkovymy krovotechamy v pre menopauzi [Characteristics of hormonal homeostasis in zhіnok s nadmіrnimi of uterine krovotech in pre menopauzі]. Bukovynskyi medychnyi visnyk, 17(2), 34–37. [in Ukrainian]. - Zotova, O. A. (2013) Adenomioz: prognozirovanie, kliniko-anamnesticheskie i molekulyarno-geneticheskie osobennosti. (Avtoref. dis…kand. med. nauk). [Adenomyosis: forecasting, medical history and clinical and molecular genetic features]. (Extended abstract of candidate’s thesis). Kemerovo. [in Russian]. - Kondrikov, N. Y. (2008) Patologiya matki [Uterine pathology]. Moscow: Prakticheskaya medicina. [in Russian]. - Maksimova, Yu. V. (2010) Kliniko-morfologicheskaya kharakteristika izmenenij e´utopicheskogo i e´ktopicheskogo e´ndometriya pri rasprostranennykh formakh genital'nogo e´ndometrioza. (Avtoref. dis… dokt. med. nauk) [Clinical and morphological characteristic of changes in eutopic and ectopic endometrium with common forms of endometriosis. Dr. med. sci. diss.]. Moscow. [in Russian]. - Adamian, L. V., Sonova, M. M., Tikhonova, E. S., Zimina, É. V., & Antonova, S. O. (2011) Medicinskie i social'nye aspekty genital'nogo e´ndometrioza [The medical and social aspects of genital endometriosis]. Problemy reprodukcii, 6, 78–81. [in Russian]. - Meliksetian, A. V., Kuryk, O. H., Kalenska, O. V., & Lysenko, B. M. (2014) Imunohistokhimichne doslidzhennia retseptoriv estrohenu i prohesteronu u vohnyshchakh henitalnoho endometriozu [Immunohistochemical studies of estrogen and progesterone receptors in the centers of endometriosis]. Ukrainskyi naukovo-medychnyi melodizhnyi zhurnal, 3(82), 71– 73. [in Ukrainian]. - Movtaeva, H. R. (2010) Kliniko-morfologicheskaya i immunogistokhimicheskaya kharakteristika . (Avtoref. dis…kand. med. nauk). [Clinical and morphological and immunohistochemical characteristics of endometriosis]. (Extended abstract of candidate’s thesis). Moscow. [in Russian]. - Samsonova, E. A. (2004) Klinicheskoe znachenie immunogistokhimicheskogo opredeleniya receptorov steroidnykh gormonov, NER2 i proliferativnoj aktivnosti kletok v rake e´ndoetriya. (Avtoref. dis…kand. med. nauk). [The clinical significance of immunoistohimicheskogo definition of steroid hormone receptors, HER2 and proliferative activity of cells in cancer endoetriya]. (Extended abstract of candidate’s thesis). Saint Petersburg. [in Russian]. - (2014) Catalog Products Services. A Better Path for Cancer Diagnostics. - Chernukha, G. E., Shigoreva, T. V., Mogirevskaya, O. A., Silakova, A. V., & Kasyan, V. N. (2011) Sex steroid hormone receptor expression and cell proliferation in different forms of endometrial hyperplasia. Impact of the levonorgestrel-releasing intrauterine system. Obstetrics and gynecology, 6, 64–69. Downloads How to Cite Issue Section License Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.