A novel whole-blood stimulation assay to detect and quantify memory T-cells in COVID-19 patients

William Mouton, Christelle Compagnon, Kahina Saker, Soizic Daniel, Xavier Lacoux, Bruno Pozzetto, Guy Oriol, Sophia Djebali, Franck Berthier, Jacqueline Marvel, Thierry Walzer, Karen Brengel-Pesce, Sophie Trouiller-Assant
2021 · doi:10.1101/2021.03.11.21253202
preprint OA: gold CC-BY-NC-ND-4.0
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Abstract

SARS-CoV-2 specific T-cells responses are essential for virus clearance. We present a novel and simple whole-blood assay allowing the detection of interferon-gamma-producing antiviral T-cells following peptide stimulation. We show that unlike neutralizing antibodies, antiviral memory T-cells persist at least 6 months in convalescent Covid-19 individuals.

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License: CC-BY-NC-ND-4.0