CA125 measured during menstruation can be misleading.

D A Crosby, DA Crosby, L E Glover, Louise Glover, Fiona M. Martyn, F Martyn, M Wingfield, Mary Wingfield
Irish medical journal · 2018 · vol. 111(4) , pp. 738 · PMID:30488683 · W2799485244
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper reports cyclical variation in serum CA-125 levels, showing a dramatic increase during menstruation in women with endometriosis.

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Abstract

The aim of these case reports and literature review is to report the importance of cyclical variation of serum CA-125 levels in two patients with endometriosis. Two case reports and a literature review of cyclical variation in serum CA-125 levels are discussed. There was significant variation in serum CA-125 levels taken during menses and mid-cycle in these two cases. Serum CA-125 levels increase dramatically during menstruation in women with endometriosis. This is important when assessing disease status.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

CA-125 Antigen Endometriosis Membrane Proteins Menstrual Cycle Menstruation Adult Biomarkers Biomarkers CA-125 Antigen Diagnostic Errors Endometriosis Female Humans Membrane Proteins Menstrual Cycle Menstruation Sensitivity and Specificity Systematic Reviews as Topic

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Cited by (2)

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europepmc
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openalex
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License: CC0 · commercial use OK