Anterior Segment Parameters on Optical Coherence Tomography in Healthy Children

Purpose To assess the anterior segment parameters in healthy children, using high resolution spectral domain optical coherence tomography (SD-OCT). Design Prospective, observational study Methods 108 eyes of 54 healthy children ≤16 years were included after a thorough eye examination. Significant refractive error (>±5 DS), history of previous glaucoma, ocular pathology, intraocular surgery, trauma or systemic ailments were excluded. The anterior segment analysis was done by Optopol Revo 80 ® high resolution SD-OCT. Central corneal thickness (CCT), Angle opening distance (AOD), Anterior chamber (AC) angle, Trabecular iris space area (TISA), Trabecular iris angle (TIA), iris thickness at 2 mm, internal AC diameter and lens vault were evaluated. Results Mean age was 11.38±3.18 years with a female predominance; 29 (53.7%). Mean IOP was 13.63±2.90 mmHg, mean axial length was 22.82±0.89 mm, mean spherical equivalent was -0.14±1.28 D, mean CCT was 532.6±46.09mm and mean CDR was 0.31±0.19. The mean internal AC diameter was 11609.15±2354 µm. The nasal AC angle was 53.54±11.82° and significantly wider than the temporal AC angle; 50.37±10.26° [p=0.008]. The nasal AOD500 was 0.9±0.33 mm and not significantly greater than the temporal AOD500, 0.85±0.28 mm [p=0.09]. The nasal AOD750 was 1.21±0.45 mm, significantly greater than the temporal AOD750, 1.06±0.32 mm [p=0.001]. The nasal TIA was 41.75°; not significantly greater than the temporal TIA, 40.24° [p=0.246]. The nasal TISA500 was 0.33±0.15 mm 2 ; not significantly wider than the temporal TISA500, 0.31±0.10 mm 2 [p=0.056]. The nasal TISA750 was 0. 59±0.22 mm 2 ; not significantly wider than the temporal TISA750, 0.56±0.21 mm 2 [p=0.14]. The nasal iris thickness at 2 mm from pupil was 483.54±129.56 µm; not significantly different from the temporal iris thickness, 505.8±138.85 µm [p=0.08]. The mean lens vault was - 519.58±359µm. Conclusions Our study data depicts the normal anterior segment parameters in healthy children. This will be useful in diagnosing and managing ocular pediatric pathology. Key Messages Anterior segment OCT is still an emerging technique especially in pediatric eye assessment Anterior segment evaluation via OCT has not been reported in our pediatric population Our study describes a detailed assessment of anterior segment in pediatric eyes Reporting results of normative data helps in diagnosing ocular pathology