Past SARS-CoV-2 infection elicits a strong immune response after a single vaccine dose

Rossana Elena Chahla, Rodrigo Hernán Tomas-Grau, Silvia Inés Cazorla, Diego Ploper, Esteban Vera Pingitore, Mónica Aguilar López, Patricia Aznar, Malena Alcorta, Eva María del Mar Vélez, Agustín Stagnetto, César Luís Ávila, Carolina Maldonado-Galdeano, Sergio Benjamín Socias, Dar Heinze, Silvia Adriana Navarro, Conrado Llapur, Dardo Costas, Isolina Flores, Gabriela Apfelbaum, Raúl Mostoslavsky, Gustavo Mostoslavsky, Gabriela Perdigón, Rosana Nieves Chehín
2021 · doi:10.1101/2021.03.14.21253039
preprint OA: closed
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Abstract

We hypothesized that in individuals with previous SARS-CoV-2 infection, the first vaccine dose would work as a booster, eliciting a faster and more intense immune response. We herein describe antibody responses to the first and second doses of Gam-COVID-Vac (SPUTNIK V) vaccine in health personnel of Tucumán, Argentina, with previous COVID-19 and compared it with uninfected personnel. Individuals with anti-SARS-CoV-2 titers at baseline showed significantly higher responses to the first dose than people with no prior history of disease (p <0.0001), with titers higher to those registered after the second dose in the control group, representing a clear secondary antibody response. This suggests that a single dose of SPUTNIK V for people with previous SARS-CoV-2 infection could contribute to a better use of available doses. One-Sentence Summary First vaccine dose in subjects with prior COVID19 elicits a higher antibody response than two doses in uninfected individuals

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