The NHANES 2011-2018 study found a negative correlation between bone mineral density and the non- high density to high density lipoprotein cholesterol ratio (NHHR) in U.S. adults

Hanwen Zhang, Jian Mei, Wei Deng
2024 · doi:10.21203/rs.3.rs-4516124/v1
preprint OA: closed CC-BY-4.0
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Abstract

Abstract Introduction Many research have shown a negative link between lipids and bone metabolism, and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) may be a new marker of lipid metabolism. The relationship between NHHR and lumbar bone mineral mass (BMD) is unknown. NHHR and lumbar BMD were the study's main focus. Method NHHR and lumbar BMD were examined using 2011-2018 National Health and Nutrition Examination Survey (NHANES) data and multivariate logistic regression models. Also employed were interaction tests and smoothed curve fitting. Result Our investigation found a connection between increased NHHR levels and decreasing lumbar BMD after adjusting for covariates. All four measurement points showed this association, and lumbar BMD decreased by 0.037 g/cm2 relative to the lowest quartile. Conclusion We discovered an interestingly negative correlation in US citizens between NHHR and lumbar BMD. This emphasizes the need of NHHR in lipid target monitoring.

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License: CC-BY-4.0