PanCircBase: An online resource for the exploration of circular RNAs in pancreatic islets

Tanvi Sinha, Smruti Sambhav Mishra, Suman Singh, Amaresh Chandra Panda
2022 · doi:10.1101/2022.04.29.490033
preprint OA: gold CC-BY-NC-ND-4.0
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Abstract

Circular RNAs (circRNAs) are a novel class of covalently closed RNA molecules that recently emerged as a critical regulator of gene expression in development and diseases. Recent research has highlighted the importance of novel circRNAs in the biosynthesis and secretion of insulin from β-cells of pancreatic islets. However, all circRNAs expressed in pancreatic islets or β-cells are not readily available in the database. In this study, we analyzed publicly available RNA-sequencing datasets of the pancreatic islets to catalog all circRNAs expressed in pancreatic islets to construct the PanCircBase ( www.pancircbase.net/ ) database that provides the following resources: (i) pancreatic islet circRNA annotation details (genomic position, host gene, exon information, splice length, sequence, other database IDs, cross-species conservation), (ii) divergent primers for PCR analysis of circRNAs, (iii) siRNAs for silencing of target circRNAs, (iv) miRNAs associated with circRNAs, (v) possible protein-coding circRNAs and their polypeptides. In summary, this is a comprehensive online resource for exploring circRNA expression and its possible function in pancreatic β-cells.

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License: CC-BY-NC-ND-4.0