AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt

Benjamin Lang, M. Madan Babu
2025 · doi:10.1101/2025.03.12.642845
preprint OA: closed CC-BY-4.0
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Abstract

Synchronizing protein structure predictions with sequence databases is crucial for their accuracy. We developed AlphaSync ( alphasync.stjude.org ), a pipeline and database that provides updated AlphaFold structure models for currently 39,961 UniProt proteins, including isoforms. Moreover, AlphaSync enhances 2.6 million structures with residue-level features, including solvent accessibility, dihedral angles, intrinsic disorder predictions, and 4.7 billion atom-level noncovalent contacts. AlphaSync’s user-friendly interface enables structural analyses at scale across up-to-date proteomes for 42 species.

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License: CC-BY-4.0