Percolation Theory Used to Design Biomolecular Condensates

Weiwei Fan
2023 · doi:10.1101/2023.11.04.565634
preprint OA: closed
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Abstract

ABSTRACT Biomolecular condensates formed by liquid-liquid phase separation (LLPS) are crucial for various life activities. Critical phenomena are observed during LLPS in cells and in vitro , but few studies provide quantitative theoretical explanations for them. In this study, we set up a Bethe network model to simulate percolation, which explains LLPS quantitatively and semi-quantitatively. We designed a condensate system to determine the peptide’s affinity to its target protein. Finally, we found that the artificial condensate can modify the catalytic reaction’s efficiency. Thus, we provide a new perspective on understanding biomolecular condensate assembly and lay the foundation for artificially designing biomolecular condensates.

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