Amino acids

Amino Acids · ISSN (e) 1438-2199 · 3 papers in corpus
2015
Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells.
doi:10.1007/s00726-015-1956-7 ·PMID:25802182

Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis. In addition to Hcy, related metabolites accumulate in HHcy but their …

2011
Physiology and pathophysiology of matrix metalloproteases.
doi:10.1007/s00726-010-0689-x ·PMID:20640864

Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on a conserved mechanism involving activation of an active site-bound water molecule by a Zn(2+) ion. Although the catalytic domain of MMPs is …

other 2010
Structural elucidation of Leuprolide and its analogues in solution: insight into their bioactive conformation
doi:10.1007/s00726-010-0549-8 ·PMID:20354741

Leuprolide [DLeu6, NHEt10]GnRH, a potent gonadotropin-releasing hormone (GnRH) agonist, is used in a wide variety of hormone-related diseases like cancer and endometriosis. In this report, the conformational behaviour of Leuprolide and its …