International journal of fertility & sterility

OBJECTIVE: Infertility remains a multifactorial disorder influenced by both genetic and environmental factors, yet the molecular interplay between these two dimensions is poorly understood. The Brca1 gene, classically known for its tumor-su…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder and a leading cause of anovulatory infertility. This study evaluated whether adding vitamin E to a regimen of letrozole, tamoxifen, and estradiol improves ovulation…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder impacting fertility. Controlled ovarian stimulation (COS) is a crucial step during in vitro fertilization (IVF) procedure to enhance oocyte retrieval and embryo …

OBJECTIVE: Alcohol sclerotherapy has been shown to reduce endometrioma recurrence and improve ovarian response, including the number of retrieved oocytes and antral follicle count (AFC), compared with surgical cystectomy. This randomized cl…

OBJECTIVE: Despite notable advances in assisted reproductive technologies (ART), pregnancy rates remain suboptimal, and improving endometrial receptivity continues to be a clinical challenge. Emerging evidence suggests that granulocyte colo…

BACKGROUND: The prognostic value of borderline and pathological sperm morphology (SM) in infertility treatment remains unclear. This study aims to evaluate the potential impact of SM on clinical pregnancy outcomes following intrauterine ins…

OBJECTIVE: Infertility arises from diverse etiologies, with polycystic ovarian syndrome (PCOS) being a leading cause among women, while male factors account for approximately 50% of cases. Selecting the most appropriate assisted reproductiv…

OBJECTIVE: Since the complications associated with endometriosis during pregnancy are rare, there is not enough evidence to indicate that this disease has major detrimental effects on pregnancy outcome. Therefore, the present study was cond…

OBJECTIVE: Polycystic ovary syndrome (PCOS) is a multifactorial, polygenic endocrinopathy with an incompletely understood aetiology that accounts for approximately 80% of female anovulatory infertility. Both genetic and environmental factor…

BACKGROUND: Recurrent implantation failure (RIF) is a challenging condition affecting approximately 10% of in vitro fertilization (IVF) patients. Despite extensive investigations, up to half of cases remain unexplained. Immune dysregulation…

OBJECTIVE: Repeated implantation failure (RIF) is a major challenge in in vitro fertilization (IVF). Insufficient uterine blood flow and reduced endometrial thickness are important factors contributing to implantation failure. Pelvic physio…

OBJECTIVE: Various studies have reported aberrant function of the immune system in endometriosis. This highly prevalent disease can initiate and progress by numerous genetic and epigenetic alterations that affect immune system functions. Re…

OBJECTIVE: Embryo transfer is a complex process that often fails due to poor endometrial growth. Pelvic floor physiotherapy improves endometrial thickness by enhancing pelvic blood circulation and stimulating uterine muscle with varied freq…

BACKGROUND: Endometriosis is a benign gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus. Proliferation of endometrial tissue and neoangiogenesis are essential factors in the development of e…

OBJECTIVE: Experimental evidence suggests that the human endometrium expresses receptors for human chorionic gonadotropin (hCG), and activation of these receptors may enhance embryo implantation. Numerous studies have explored the effects o…

BACKGROUND: Hydrosalpinx is a recognized condition affecting the fallopian tubes, which decreases the embryo implantation rate and success in in vitro fertilization (IVF) outcomes. It can manifest detrimental effects through inflammatory co…

BACKGROUND: This study aimed to investigate whether uterine cavity flushing combined with antibiotic administration, improves the outcomes of assisted reproductive technology for patients with thin endometrium (<7 mm) associated with chroni…

BACKGROUND: The success rate of in vitro maturation (IVM) for human oocytes is clinically significant, prompting a focus on optimizing IVM media culture. While various factors have been incorporated to improve outcomes, the role of Ghrelin …

BACKGROUND: This study aims to evaluate the crucial relationship between the follicular distribution pattern (FDP) in polycystic ovaries and its impact on reproductive outcomes. Recognizing these correlations is essential for optimizing ass…

BACKGROUND: Endometriosis is a complex, heterogeneous disease with several genetic and non-genetic pathogenic factors. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway may influence bo…

BACKGROUND: Endometriosis is among the leading causes of morbidity in the female population worldwide. Currently, the definite diagnosis of endometriosis depends on laparoscopy as the gold-standard method. Potential biomarkers, such as infl…

BACKGROUND: Endometriosis is a prevalent women's health disorder that lacks a definitive cure. Numerous studies have been conducted to identify the underlying causes of this disease and select the most effective pharmaceutical intervention.…

BACKGROUND: Endometriosis is an estrogen-dependent disease. Cytochrome P450 aromatase which encoded by CYP19A1 is a key enzyme in the pathway of estrogen biosynthesis. cAMP response element (CRE) binding protein (CREB) and cAMP response ele…

BACKGROUND: Chromosomal mosaicism, a phenomenon observed in a minority of embryos, showcases its prevalence and inherent unpredictability, leading to variations in embryo mosaic rates across different centers. This research endeavors to ass…

BACKGROUND: Defects in endometrial receptivity are significant factors in infertility and recurrent implantation failure (RIF) during in vitro fertilization (IVF). This study aimed to evaluate the expression levels of steroid hormone recept…