Reproductive medicine and biology

PurposeThe cervicovaginal microbiota is essential for maintaining the health of the female reproductive tract. However, whether cervicovaginal microbiota status prior to frozen embryo transfer (FET) associates with pregnancy outcomes is lar…

PURPOSE: We evaluated factors affecting the development of endometrial receptivity according to age and changes in the endometrial microbiota. METHODS: We recruited patients with infertility who underwent transcriptomic analyses of endomet…

PurposeThe purpose of this study is to compare anthropometric measurements between term singletons conceived via fresh embryo transfer (FreET) and frozen embryo transfer (FET) and those born via natural conception (NC) or fertility treatmen…

PurposeTo evaluate clinical outcomes after endometrial receptivity analysis (ERA).MethodsThis was a multicenter, retrospective cohort study involving 861 women who underwent ERA testing at certified fertility clinics in Japan, and who recei…

PURPOSE: To test the theory that invaginated ovarian surface epithelium and endometrial implants on the ovary form ovarian endometriomas. METHODS: Adhesion sites of ovarian endometrioma on the peritoneum and consecutive ovarian endometriom…

PURPOSE: The aim of this study was to evaluate the dynamic change in staining of Class I HDACs and Hdac6 in lesions harvested serially from different time points in mice with induced endometriosis. In addition, the effect of Hdac8 activatio…

PURPOSE: This study aimed to examine the embryonic development of human 4-cell stage embryos after warming with fatty acids (FAs) and to assess the pregnancy outcomes after single vitrified-warmed cleavage stage embryo transfers (SVCTs). M…

PURPOSE: This study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis. METHODS: Of seven cynomolgus monkeys with endometriosis, five were administered…

BACKGROUND: Cesarean scar defects (CSD) are caused by cesarean sections and cause various symptoms. Although there has been no previous consensus on the name of this condition for a long time, it has been named cesarean scar disorder (CSDi)…

PURPOSE: The MiOXSYS system is a new technique to analyze the semen oxidative reduction potential (ORP) that may use to classify the level of sperm DNA integrity. It does not clearly explain how the semen ORP values could help to change the…

PURPOSE: To analyze whether response to the GnRH test is a predictor of empty follicle syndrome (EFS) and to analyze independent risk factors for EFS. METHODS: The GnRH test results of 3765 patients from 2016 to 2018 were used to define th…

PURPOSE: This study aimed to investigate whether serum leucine-rich α2-glycoprotein (LRG) is a useful diagnostic biomarker for endometriosis, including the evaluation of treatment efficacy and exploration of LRG production in endometriotic …

PURPOSE: A cross-sectional study was conducted to evaluate differences in uterine morphology between women with or without polycystic ovary syndrome. METHODS: The authors recruited 333 infertile reproductive-age women including 93 with pol…

PURPOSE: Vaginal progesterone (VP) alone has been used as luteal support (LS) in HRT-FET cycles without measuring serum progesterone concentrations (SPC) because it can achieve adequate intrauterine progesterone levels. However, several rep…

This is the first guidelines for adenomyosis from the Asian Society of Endometriosis and Adenomyosis.

PURPOSE: To create a gonadotropin starting dose calculator for controlled ovarian stimulation, which can adjust the target number of oocytes and stimulation duration for each facility to achieve individualized controlled ovarian stimulation…

PURPOSE: To evaluate the impact of embryo banking on the cumulative live birth rate (CLBR) and the time to live birth (TTLB) in poor ovarian responders (POR) according to the Bologna criteria. METHODS: A total of 276 infertile women underg…

PURPOSE: To identify the efficacy of endometrial curettage on antibiotic-resistant chronic endometritis (CE) in infertile women. METHODS: Of 1580 women with CE, 87 with antibiotic-resistant CE after two to five cycles of antibiotic treatme…

PURPOSE: Ovarian tissue cryopreservation and its auto-transplantation is promising technique in fertility preservation. Longevity of grafted tissue is limited though mechanism of follicle reduction is not fully understood. We evaluated hist…

PURPOSE: To analyze the characteristics of the ovarian endometrioma (OE) across the life span of a woman. In the past, the OE has traditionally been viewed as a single, monolithic disease. Today, there are emerging data indicating that OE p…

PURPOSE: To evaluate the efficacy of an oral gonadotropin-releasing hormone antagonist (GnRH Ant), relugolix (R), for assisted reproductive technology (ART). METHODS: We enrolled women undergoing ART using a GnRH Ant for controlled ovarian…

PurposeThis study aimed to analyze whether tripronuclear (3PN) zygotes, with two normal-sized PNs and an additional smaller PN (2.1PN), can be used for embryo transfer.MethodsA retrospective embryo cohort study was conducted on 695 patients…

PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4-6 follicles ≥14 mm. METHODS: A retrospective case-control study with 1559 patients under…

PURPOSE: Our aim is to make an ideal embryo culture medium close to human oviduct fluid (HOF) components, and to evaluate the quality of this medium with embryo quality and clinical outcomes in assisted reproductive technology (ART) by a pr…

PURPOSE: To determine the utility of short gamete coincubation in in vitro fertilization (IVF-S) combined with early rescue intracytoplasmic sperm injection (R-ICSI) and split IVF-ICSI in preventing low fertilization based on a retrospectiv…