Journal of the Endocrine Society

Abstract Pediatric adrenocortical tumors (pACT) are rare, display complex genomic background and lack robust prognostic markers. Very recently, distinct genomic methylation profiles of pACT were associated with prognosis. The vitamin D rece…

Abstract This is a case of a 41 year old Filipino female, with one month history of palpitations, unintentional weight loss and increased frequency of bowel movement. Patient was tachycardic and had a slightly enlarged thyroid on physical e…

Abstract Introduction: We present a rare case of ectopic Cushing syndrome (CS) due to a neuroendocrine tumor (NET) metastatic to the breast. Case: A 38-year-old female was referred for ACTH-dependent CS. She had rapid development of cushing…

Abstract The thermogenic potential of brown adipose tissue (BAT) is a promising therapeutic target in the treatment of obesity and metabolic disorders. The preoptic area (POA) is a region in the anterior hypothalamus responsible for autonom…

Abstract Introduction: Uterine fibroids (UF) affect up to 25% of women and endometriosis (EM) 10% of women worldwide. An ideal therapy would lower estradiol concentrations to reduce hormonal drive to the endometrium and myometrium, but not …

Abstract Patients with cystic fibrosis (CF) are at risk for cystic fibrosis-related bone disease (CFBD) characterized by low bone mineral density and fractures. Nutritional status, cystic fibrosis-related diabetes (CFRD), lung health, and s…

Abstract Endometriosis is an estrogen-dependent disorder defined by endometrium-like tissue outside the uterine cavity that results in pelvic inflammation. Pro-inflammatory cytokines can increase 11 β -hydroxysteroid dehydrogenase type 1 (1…

Abstract Background: Homozygous mutations in lamin A/C (LMNA) gene are extremely rare and have been reported to cause mandibuloacral dysplasia type A, Emery-Dreifuss muscular dystrophy-3, Charcot-Marie-Tooth axonal neuropathy type 2B1, prog…

Abstract Development of painful invasive endometriotic lesions is usually a combined function of the chronic inflammation and active sequential cellular events such as migration, cell adhesion, proliferation, colonization, and invasion in e…

Abstract Endometriosis (EMS) is a debilitating gynecologic disease characterized by the presence of endometrial glands and stroma outside the uterus. Symptoms caused by this disease have serious implications for women's lives and health. Al…

Abstract [Background]Endometriosis is an estrogen-dependent, inflammatory disease characterized by the presence of endometrium-like tissue primarily on the pelvic peritoneum and ovaries. There is accumulating evidence suggesting epigenetic …

Abstract Incidental adrenal adenoma (AI) may be a marker for other illnesses, especially cardiovascular diseases. However, most of these studies have included men and women with mean ages >50 yrs. AI in reproductive age women has not been i…

CONTEXT: Progesterone (P) resistance is a hallmark of endometriosis, but the underlying mechanism(s) for loss of P sensitivity leading to lesion establishment remains poorly understood. OBJECTIVE: To evaluate the association between Notch-…

Acromegaly is usually not a difficult condition to diagnose once the possibility of this disease has been raised. However, a few conditions present with some aspects of acromegaly or gigantism but without growth hormone (GH) excess. Such ca…

CONTEXT: Resveratrol has been used for the treatment of endometriosis. OBJECTIVE: To compare resveratrol (40 mg/d) with monophasic contraceptive pill (COC) to COC with placebo for the reduction of pain scores. DESIGN: A randomized clinica…