RSC advances

MicroRNAs (miRNAs), a category of small (18-25 nucleotides) non-coding transcripts that modulate gene expression at the post-transcriptional level, are necessary for regulatory processes in female reproduction, specifically in ovarian funct…

Infertility represents a significant global health burden, necessitating advanced therapeutic interventions. While Assisted Reproductive Technologies have revolutionized fertility treatment, they remain constrained by limited efficacy, off-…

The extraction methods of berberine hydrochloride include water, acidified water, lime milk, and ethanol extraction. The water extraction method is mainly a decoction method, whereas the alcohol extraction method mainly includes microwave, …

Ovarian cancer is one of the leading causes of mortality among women worldwide. However, early detection can significantly reduce mortality rates and mitigate subsequent complications related to both economic burden and mental well-being. D…

Pancreatitis is a life-threatening inflammatory disease of the pancreas. In 2019, 34.8 out of 100 000 people suffered from acute pancreatitis globally. In humans, the level of α-amylase increases three times the normal value during pancreat…

Human amniotic membrane (hAM) is a promising material for tissue engineering due to several benefits, including desirable biocompatibility, stem cell source, antibacterial activity, etc. However, because of its low elasticity, the clinical …

Steroidal estrogens (SEs) remain one of the notable endocrine disrupting chemicals (EDCs) that pose a significant threat to the aquatic environment in this era owing to their interference with the normal metabolic functions of the human bod…

Herein, a new series of N-substituted 1,2,3-triazolylmethyl indole derivatives 4(a-u) was synthesized by rationally incorporating a pharmacophoric active heterocyclic ring containing indole and triazole moieties in one molecular frame via t…

Ovarian cancer is an important leading cause of cancer-related deaths among females, and a single biomarker does not have the sensitivity and specificity required for an effective ovarian cancer screening. Herein, we investigate a high-perf…

Fluorometric quantification of biological molecules is a key feature used in many biosensing studies. Fluorescence resonance energy transfer (FRET) using highly fluorescent quantum dots offers highly sensitive detection of the in-proximity …

Hydroxyethyl starch (HES) is a commonly used intravenous fluid in hospital settings. The merits and demerits of its application is still a debatable topic. Investigating the interaction of external agents like intravenous fluids with blood …

Kinase proteins have been intensively investigated as drug targets for decades because of their crucial involvement in many biological pathways. Most kinase drugs target the catalytic ATP pocket, which is highly conserved across the kinome,…

Based on the multifunctional ligand 3-(1H-1,2,4-triazol-1-yl)isophthalic acid (H2TIA), a three-dimensional coordination polymer, namely {[Zn(TIA)]·DMA} n (Zn-1) was synthesized solvothermally. Single-crystal X-ray diffraction analyses confi…

Numerous studies have revealed that the status of intestinal microbiota has a marked impact on inflammation, which may progressively aggravate the systemic inflammatory response caused by acute pancreatitis (AP). However, our understanding …

)). We initially confirmed that PF could significantly regulate the metabolic expression of multiple metabolic pathways in the ECB model rats. For the first time, this study explored the mechanism of action of PF treatment based on the meta…

Essential hypertension (EH) is a chronic disease characterized by a variety of causes of elevated systemic arterial pressure, which often causes functional or organic damage to important organs such as the heart, brain, and kidney. Hyperten…

The current study was designed to evaluate the phytochemical profile and biological properties (antioxidant, enzyme inhibitory and cytotoxic activity) of methanolic, ethanolic, ethyl-acetate and water extracts of Alchemilla vulgaris from So…

Long noncoding RNAs have been widely accepted to play important roles in acute myocardial infarction (AMI). The dysregulation of cyclin-dependent kinase inhibitor 2B antisense RNA 1 (ANRIL) was discovered in AMI patients. Nevertheless, the …

The abnormal expression of miRNAs is directly related to the development of human diseases. Predicting the potential candidate miRNAs associated with diseases can contribute to the detection, diagnosis, treatment and prevention of human com…

Metabolomics is an emerging and robust discipline and involves the comprehensive evaluation of small molecule endogenous metabolites and enables the exploration of the pathogenesis of diseases. For example, endometriosis - a common disease …