The Lancet regional health. Europe

BACKGROUND: Miscarriage and ectopic pregnancy are among the most common early pregnancy complications, yet contemporary national trends and associated inequalities in England remain poorly characterised. This study examined 20-year temporal…

BACKGROUND: A decrease in oral contraceptive use, newly available methods, and the emerging role of midwives suggested meaningful changes in contraception use in France. With two repeated cross-sectional studies, we aimed to describe contra…

BACKGROUND: Even though abdominal pain is one of the most frequent chief complaints in emergency medicine, standardized care pathways are still lacking. In this study, a standardized, digitally-supported care pathway for non-traumatic abdom…

BACKGROUND: Use of the high-dose levonorgestrel-releasing intrauterine system (LNG-IUS) has been associated with increased risk of incident depression. Evidence is lacking on the influence of use of two recently marketed low-dose LNG-IUS on…

BACKGROUND: Autistic people are disproportionately likely to experience premature mortality and most mental and physical health conditions. We measured the incidence of diagnosed conditions accounting for the most disability-adjusted life y…

BACKGROUND: Nomegestrol acetate (NOMAC) is a synthetic potent progestogen. This study aimed to assess the risk of intracranial meningioma associated with the prolonged use of NOMAC. METHODS: Observational cohort study using SNDS data (Fran…

BACKGROUND: Opportunistic salpingectomy to reduce ovarian cancer incidence has become increasingly common despite the lack of randomised trials investigating its safety. In SALSTER, we tested whether salpingectomy for laparoscopic sterilisa…

BACKGROUND: Evidence on a possible association between newer hormonal contraceptives (HC) and risk of breast cancer remains inconclusive, especially as concerns progestogen-only methods. METHODS: In this nationwide prospective cohort study…

BACKGROUND: We aimed to identify specific patterns of physical multimorbidity, defined as the presence of two or more physical long-term conditions, and to examine the extent to which these specific patterns could predict future incident an…