Frontiers in bioinformatics

· 3 papers in corpus
2026
Integrative transcriptomics and structure-based screening identifies Phyllanthus amarus phytocompounds as potential WNT5A modulators in ovarian cancer.
doi:10.3389/fbinf.2026.1815548 ·PMID:42253320

IntroductionOvarian cancer is one of the most lethal gynecological malignancies, largely due to its asymptomatic onset, heterogeneous molecular landscape, and frequent late-stage diagnosis. Identifying key oncogenic drivers and novel therap…

2025
In silico analysis of CSF2RB from cancer genomic databases reveals a heterogeneous role in different breast cancer subtypes.
doi:10.3389/fbinf.2025.1606828 ·PMID:40837403

ObjectiveCSF2RB is the common beta chain of the heterodimeric receptors for the cytokines, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), and interleukin 5 (IL-5). The activation of these cell surface recep…

2025
REST missense mutations reveal disrupted Re1 motif binding and co-repressor interactions in uterine fibroids.
doi:10.3389/fbinf.2025.1703356 ·PMID:41601477

IntroductionThe Re1-Silencing Transcription Factor (REST) is a master regulator of gene silencing, orchestrating transcriptional repression by tethering chromatin-modifying co-repressors to the Re1 motif of target genes. While REST is recog…