Frontiers in immunology

ObjectiveChronic pancreatitis (CP) creates an inflammatory pancreatic microenvironment and is an established risk factor for pancreatic cancer (PC). However, immune-inflammatory links between CP and PC remain unclear. Isorhamnetin (ISO), a …

Endometriosis (EMS) is a common gynecological disease that seriously affects women's health and quality of life. However, the detailed dynamic cellular and molecular mechanisms underlying EMS pathogenesis remain largely unknown. This study …

Ferroptosis is an iron-dependent form of programmed cell death driven by lipid peroxidation, distinct from apoptosis and necrosis. It has been confirmed as a key regulator in hepatocellular carcinoma (HCC). This study systematically elucida…

Pelvic organ prolapse (POP) is a prevalent condition that significantly impairs women's quality of life and is closely linked to dysregulated estrogen signaling. This review examines the mechanisms through which estrogen, acting via nuclear…

Nociplastic pain (NPP) is a recently defined form of chronic pain, characterized by altered nociception in the absence of clear evidence of nociceptive or neuropathic pain. It is believed to be driven by maladaptive changes in nociceptive p…

BackgroundRecurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) are major causes of pathological early pregnancy, yet their mechanisms remain poorly understood. This study aimed to identify shared molecular mediators and t…

The fat mass and obesity-associated protein (FTO), an RNA demethylase acting on both internal m6;A and cap-proximal m6;Am, functions in cancer as a context-dependent epitranscriptomic regulator whose net effect cannot be reduced to an oncog…

This study builds upon existing research achievements in bioinformatics to systematically screen a comprehensive set of biomarkers and prognostic models associated with immune infiltration regulation in the tumor microenvironment of endomet…

Eosinophils are evolutionarily conserved granular innate cells that can trace back to 100 million years to the emergence of gnathostomes, which now is involved in regulation of diverse homeostatic conditions and diseases in mammals. They ha…

Gynecologic cancers (GCs), including ovarian, cervical, and endometrial cancers, represent a substantial global health burden, characterized by high rates of recurrence, therapeutic resistance, and metastatic dissemination. Tumor dormancy-a…

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone proteins. This modif…

IntroductionCeliac disease (CD) is an immune-mediated enteropathy triggered by gluten ingestion in genetically predisposed individuals and represents a frequent but underdiagnosed cause of iron deficiency (ID). Screening for CD is recommend…

IntroductionTo assess the prevalence and clinical impact of antinuclear antibodies (ANA) and low complement levels on fetal-maternal outcomes in pregnant women within the spectrum of obstetric antiphospholipid syndrome (APS).MethodsA total …

BackgroundUnexplained recurrent implantation failure (URIF) represents a complex and challenging condition in reproductive medicine, while the role of non-criteria antiphospholipid syndrome antibodies in its pathogenesis remains unclear. As…

Cancer progression and therapeutic response remain highly variable across tumor types and are not fully explained by tumor-intrinsic alterations alone. The human microbiome has emerged as a systems-level regulator of cancer biology, integra…

INTRODUCTION: Endometriosis (EMs) is increasingly recognized as a chronic inflammatory disease in which innate immune dysregulation plays an important role. Its immunopathological features include macrophage polarization imbalance, with M1-…

Endometriosis (EM) is a chronic, inflammatory gynaecological disorder defined by the presence of endometrial-like tissue outside the uterine cavity, most frequently affecting the ovaries, peritoneum, and uterosacral ligaments. Despite its p…

ObjectiveTo investigate the impact of thyroid autoimmunity (TAI) on fertilization outcomes in euthyroid infertile women undergoing in vitro fertilization-embryo transfer (IVF-ET), and to identify key follicular fluid exosomal miRNAs associa…

IntroductionA balanced endometrial immune profile is considered to be the ideal environment for a successful implantation, as opposed to endometrial immune dysregulation. However, the embryo quality may be the pivotal 'immune' factor compar…

BackgroundTraditional research on the female reproductive tract (FRT) microbiome has focused on the dominance of bacteria, particularly Lactobacillus, as a marker of health. This bacteriocentric paradigm, however, cannot fully explain clini…

IntroductionInterleukin-24 (IL-24) is a cytokine belonging to the IL-10 family with immunoregulatory properties. It is known to induce cellular responses in various disease conditions, including inflammatory, infectious diseases, and cancer…

Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination and routine screening. The cGAS…

Chemokines, a category of cytokines exhibiting chemotactic properties, have been thoroughly investigated as targets in cancer treatment in recent decades. In oral squamous cell carcinoma (OSCC), a prevalent and high-risk malignancy of the h…

BACKGROUND: Molecular events that drive endometriosis (EM) and cause accompanying immune deregulation remain elusive. Our purpose was to identify key pathways involved in lesion formation across diverse populations and to detect transcripto…

[This corrects the article DOI: 10.3389/fimmu.2023.1115504.].