Molecular genetics and metabolism reports

Mol Genet Metab Rep · ISSN (print) 2214-4269 · 2 papers in corpus
other 2022
Elagolix is porphyrogenic and may induce porphyric attacks in patients with the acute hepatic porphyrias
doi:10.1016/j.ymgmr.2022.100915 ·PMID:36105850

Elagolix is an FDA-approved treatment for moderate-to-severe pain associated with endometriosis but has been associated with increased acute porphyric attacks in women with the acute hepatic porphyrias (AHPs). A fluorescence-based screening…

2019
Bi-directional Mendelian randomization of epithelial ovarian cancer and schizophrenia and uni-directional Mendelian randomization of schizophrenia on circulating 1- or 2-glycerophosphocholine metabolites.
doi:10.1016/j.ymgmr.2019.100539 ·PMID:31844628

Most women with epithelial ovarian cancer (EOC) present with late-stage disease. As a result, globally, EOC is responsible for >150,000 deaths a year. Thus, a better understanding of risk factors for developing EOC is crucial for earlier sc…