Frontiers in human neuroscience

ObjectiveHormonal contraceptives (HCs) are linked to mood disturbances, but the neurobiological mechanisms remain unclear. This study investigated whether HC use is associated with altered central serotonergic activity, using the loudness d…

IntroductionPain perception greatly varies among individuals and represents a major clinical challenge. Current pain assessment relies on subjective reports; although straightforward, these cannot distinguish the diverse underlying pathophy…

Our brain constantly integrates afferent information, such as visual and tactile information, to perceive the world around us. According to the maximum-likelihood estimation (MLE) model, imprecise information will be weighted less than prec…

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migrai…

A major challenge in neuroscience is to understand what happens to a brain as it ages. Such insights could make it possible to distinguish between individuals who will undergo typical aging and those at risk for neurodegenerative disease. O…

Chronic postsurgical pain (CPSP) occurs in up to 50% of individuals after surgeries and 32% after hysterectomy, leading to major adverse effects on quality of life and socioeconomic burden. Little is known about whether and how large-scale …