Frontiers in oncology

BACKGROUND: Uterine adenosarcoma is a rare malignant tumor characterized by a biphasic pattern consisting of benign epithelial components and sarcomatous stroma. The subtype with sarcomatous overgrowth is more aggressive and poses significa…

OBJECTIVE: This study aimed to develop an ultrasound-based deep learning radiomics nomogram for differentiating endometrial hyperplasia with polyps from endometrial cancer in endometrial lesions and to explore its clinical diagnostic effica…

INTRODUCTION: Ovarian clear cell carcinoma (OCCC) frequently arises in association with endometriosis and is characterized by iron-rich oxidative stress, hypoxia-responsive metabolic reprogramming, glycogen accumulation, and alterations in …

PURPOSE: Adenomatoid tumor (AT) of the uterus is a rare benign neoplasm of mesothelial origin. To date, few studies have reported the magnetic resonance imaging (MRI) findings and clinicopathologic features of uterine ATs. This study aimed …

Tumor heterogeneity is a core challenge in gynecologic oncology, driving therapeutic resistance and limiting the efficacy of single-point biopsies. Artificial intelligence (AI) and radiomics are emerging as a "digital biopsy" to non-invasiv…

BACKGROUND: Epidemiologic evidence on the association between infertility and thyroid cancer risk remains inconsistent. We conducted a systematic review and meta-analysis to synthesize available observational evidence and quantify this asso…

OBJECTIVE: To evaluate the association between hormone therapy and the development, progression, and treatment response of spheno-orbital meningiomas (SOMs) and to identify current evidence gaps in clinical management. METHODS: A systemati…

BACKGROUND: Pelvic floor dysfunction (PFD) is a common functional disorder following total hysterectomy. Currently, the assessment mainly relies on manual measurements of transperineal ultrasound (TPUS) images, which suffers from low effici…

Current anti-angiogenic therapies using vascular endothelial growth factor-A/vascular endothelial growth factor receptor-2 (VEGF-A/VEGFR2) inhibitors lack dynamic biomarkers that can facilitate patient selection and optimize dosing; this ca…

INTRODUCTION: Serous surface papillary borderline ovarian tumors (SSPBOTs), a clinically distinct variant of serous borderline ovarian tumors (SBOTs), are frequently misdiagnosed as malignant tumors during preoperative diagnostic assessment…

BACKGROUND: Cases of primary clear cell adenocarcinoma of the vagina (PCCAV) are infrequently encountered and account for only 5%-10% of all primary vaginal cancers 1. The most common associated risk factor for developing PCCAV is in utero …

Uterine leiomyoma is a common benign tumor of the uterus and typically demonstrates low FDG uptake on 18F-FDG PET/CT. Intense FDG uptake in a uterine mass is generally considered suggestive of malignancy. Here, we report a case of uterine l…

BACKGROUND: Fumarate hydratase (FH)-deficient uterine leiomyoma is a rare pathologic marker for hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Its recognition is crucial for initiating life-saving surveillance. CASE P…

OBJECTIVE: To present two cases of primary ovarian squamous-cell carcinoma (POSCC) and describe a comprehensive review and analysis of the published related literature. METHODS: We reviewed the medical records of two patients with POSCC wh…

BACKGROUND: Large-cell neuroendocrine carcinoma (LCNEC) of the female genital tract is rare and highly aggressive. When the dominant tumor burden is intramyometrial, preoperative imaging may mimic benign myometrial disease and delay oncolog…

Deep infiltrating endometriosis (DIE) is a severe form of endometriosis that rarely undergoes malignant transformation, and when it does, diagnosis is often difficult. Here, we report two cases of long-standing DIE that progressed to endome…

Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10 ye…

[This corrects the article DOI: 10.3389/fonc.2022.859510.].

Pelvic ectopic kidney is a rare congenital anomaly, occurring in approximately 0.1% of the adult population, and is often asymptomatic. However, it can easily be mistaken for a pelvic tumor or lymph-node metastasis. This case report details…

INTRODUCTION: Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy, and accurate prediction of long-term survival remains challenging. This study aimed to evaluate the prognostic associations of prespecified clin…

BACKGROUNDS: The preoperative differentiation of borderline ovarian epithelial tumors (BOETs) remains challenging. While systemic inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and…