Neurobiology of aging

2023

doi:10.1016/j.neurobiolaging.2023.01.005 ·PMID:36827943

Age-related changes in cognition, brain morphology, and behavior are exhibited in several primate species. Baboons, like humans, naturally develop Alzheimer's disease-like pathology and cognitive declines with age and are an underutilized m…

2013

Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys.

doi:10.1016/j.neurobiolaging.2012.12.017 ·PMID:23369546

Preclinical studies in aged, surgically-menopausal rhesus monkeys have revealed powerful benefits of intermittent estrogen injections on prefrontal cortex-dependent working memory, together with corresponding effects on dendritic spine morp…

2009

Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study.

doi:10.1016/j.neurobiolaging.2007.08.003 ·PMID:17889406

ObjectiveTo determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women.BackgroundSeveral single nucleotide polymorphisms (…