Neurobiology of aging

other 2023

doi:10.1016/j.neurobiolaging.2023.01.005 ·PMID:36827943

Age-related changes in cognition, brain morphology, and behavior are exhibited in several primate species. Baboons, like humans, naturally develop Alzheimer's disease-like pathology and cognitive declines with age and are an underutilized m…

lab-animal 2013

Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys

doi:10.1016/j.neurobiolaging.2012.12.017 ·PMID:23369546

Preclinical studies in aged, surgically-menopausal rhesus monkeys have revealed powerful benefits of intermittent estrogen injections on prefrontal cortex-dependent working memory, together with corresponding effects on dendritic spine morp…

observational 2011

Premenopausal hysterectomy is associated with increased brain ferritin iron

doi:10.1016/j.neurobiolaging.2011.08.002 ·PMID:21925770

Iron is essential for triggering oligodendrocytes to myelinate, however, in gray matter (GM) iron increases with age and is associated with age-related degenerative brain diseases. Women have lower iron levels than men, both in the peripher…

observational 2009

Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study

doi:10.1016/j.neurobiolaging.2007.08.003 ·PMID:17889406

OBJECTIVE: To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women. BACKGROUND: Several single nucleotide polymorph…