British journal of clinical pharmacology

Br J Clin Pharmacol · ISSN (e) 1365-2125 · 2 papers in corpus
rct 2022
doi:10.1111/bcp.15358 ·PMID:35437837

AIMS: Neuronal hypersensitisation due to adenosine triphosphate-dependent P2X3 receptor signalling plays a significant role in several disorders including chronic cough and endometriosis. This first-in-human study of eliapixant (BAY 1817080…

article 2021
doi:10.1111/bcp.15171 ·PMID:34904270

AIMS: To identify linzagolix doses, an oral GnRH receptor antagonist, that effectively lower oestradiol (E2) to relieve endometriosis-related pelvic pain without compromising bone health. METHODS: Integrated statistical, pharmacokinetic-pha…