Alimentary pharmacology & therapeutics

BackgroundTreatment options for medically-refractory faecal incontinence (FI)-including anorectal biofeedback, dextranomer injection, and sacral nerve stimulation-are limited and outcomes are often suboptimal. Anal or vaginal insert devices…

BACKGROUND: Gastrointestinal symptoms affect most women with endometriosis, but therapeutic interventions are poorly defined. AIMS: To compare the effects of a 28-day low fermentable oligo-, di- and mono-saccharides and polyols (FODMAP) or…

We compared ovarian cancer incidence between women with and without an index irritable bowel syndrome (IBS) diagnosis using administrative claims data. Risk of ovarian cancer was higher at 3 (hazard ratio [HR] = 1.71, 95% CI: 1.08-2.70, p =…

BackgroundThere is a female predominance of diagnosed coeliac disease with sex-related differences in clinical presentation. Delayed menarche, infertility and pregnancy complications have been linked to poor nutritional status and autoimmun…

BackgroundHow contraceptive formulation, dose, duration of therapy and mode of delivery affects the risk of inflammatory bowel disease (IBD) is poorly described.AimTo examine associations between types of hormonal contraception and developm…

BackgroundOff-label prescribing is encountered across various fields of medicine and creates alternative treatment options, but is associated with unknown safety risks. The use of off-label drugs for the treatment of patients with inflammat…

BackgroundPancreatic exocrine insufficiency (PEI) results in maldigestion, leading to abdominal pain, steatorrhoea, malnutrition and weight loss.AimTo assess the efficacy and safety of pancreatin (Creon 40000 MMS) in treating PEI due to chr…

BackgroundThe burden of functional GI disorders and their associations with psychological distress in women veterans is unclear.AimTo examine 1-year prevalence of irritable bowel syndrome (IBS) and dyspepsia symptoms and their associations …