Regulatory toxicology and pharmacology : RTP

Regul Toxicol Pharmacol · ISSN (e) 1096-0295 · 2 papers in corpus

other 2020

Clinical epidemiology studies on potential effects of endocrine disrupting chemicals (EDCs) should exclude subjects with obesity as determined by BMI

doi:10.1016/j.yrtph.2020.104711 ·PMID:32598900

Obesity as determined by BMI is a confounder in clinical evaluations of the effects of endocrine disrupting chemicals (EDCs). Validated regulatory tests are used to determine whether a chemical acts via a mode of action (MOA) that affects e…

other 2015

A critical examination of the mode of action of quinacrine in the reproductive tract in a 2-year rat cancer bioassay and its implications for human clinical use

doi:10.1016/j.yrtph.2015.02.006 ·PMID:25680263

A rat carcinogenicity bioassay (CaBio) of quinacrine was reanalyzed to investigate its mode of tumor induction. Quinacrine's effects in the rat uterus when administered as a slurry in methylcellulose were contrasted with the human clinical …