Human reproduction (Oxford, England)

STUDY QUESTION: What is the effect of progesterone administered via vaginal oil capsules versus pessaries, on clinical outcomes, when used for luteal phase support (LPS) in ART? SUMMARY ANSWER: Our study findings indicate a higher live bir…

STUDY QUESTION: Do the genetic and clinical outcomes of monopronuclear blastocysts (MPBs) differ between standard insemination and intracytoplasmic sperm injection cycles, and what do these differences imply for risk stratification and indi…

STUDY QUESTION: Does anti-Müllerian hormone (AMH) influence preantral follicle development within a short range of AMH-secreting antral follicles? SUMMARY ANSWER: Immunization of sheep against AMH leads to increased follicle survival, spec…

STUDY QUESTION: Is the live birth rate higher for cleavage stage embryos compared to blastocysts in patients with a single zygote following oocyte fertilization using IVF or ICSI? SUMMARY ANSWER: Among patients with only a single zygote, t…

STUDY QUESTION: Is the endometrial microbiome altered in women who fail to get pregnant after ART and do microbial-derived metabolites influence endometrial cellular mechanisms important for embryo implantation? SUMMARY ANSWER: The endomet…

STUDY QUESTION: Does ICSI improve the live birth rate in couples without severe male factor infertility compared to conventional IVF (cIVF)? SUMMARY ANSWER: High-quality evidence showed no benefit of ICSI over cIVF in improving live birth …

STUDY QUESTION: What are experiences of infertility-related traumatic events and are these associated with symptoms of Post-Traumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD)? SUMMARY ANSWER: Infertility-related trauma results from …

STUDY QUESTION: What is the association between treated (ART, ovulation induction (OI)) and untreated subfertility and risk of cerebral palsy (CP)? SUMMARY ANSWER: There is no increased risk of CP in births to subfertile untreated women; t…

STUDY QUESTION: Does germinal vesicle (GV) rescue by IVM provide a meaningful clinical benefit in patients with unexpectedly low mature oocyte yield, and which patient profiles are most likely to benefit? SUMMARY ANSWER: Especially in pati…

Study questionTo what extent does multiple birth mediate the association between fertility treatment and congenital anomalies?Summary answerMultiple birth explained only a modest proportion of the increased risk of congenital anomalies asso…

STUDY QUESTION: Does endometrial gene expression change across consecutive cycles and after endometrial injury? SUMMARY ANSWER: Although paired endometrial samples collected from the same woman across two consecutive cycles show greater si…

STUDY QUESTION: How does the efficacy of linzagolix (a gonadotropin-releasing hormone [GnRH] receptor antagonist) compare with leuprorelin (a GnRH agonist) for the treatment of heavy menstrual bleeding (HMB) in patients with uterine leiomyo…

Recent advances in the development of stem-cell-based embryo models and endometrial assembloids have fuelled understanding of their respective biology. However, a faithful combined approach is required to truly advance our understanding of …

STUDY QUESTION: What is the effect of Virtual Reality (VR) on anxiety and pain during oocyte retrieval in IVF/ICSI treatment? SUMMARY ANSWER: There is no significant effect of VR on anxiety and pain during oocyte retrieval in IVF/ICSI trea…

Study questionDoes progesterone-based embryo transfer timing achieve live birth rates comparable to LH-surge-based timing in true natural cycle frozen embryo transfer (NC-FET)?Summary answerProgesterone-based embryo transfer timing was asso…

STUDY QUESTION: What is the recommended prevention, diagnosis, and treatment of infertility among individuals and couples? SUMMARY ANSWER: The World Health Organization (WHO) made 40 recommendations and six good practice statements for the…

STUDY QUESTION: What updates of the International Glossary on Infertility and Fertility Care are required, to reflect contemporary scientific knowledge, social needs, and inclusive definitions, while harmonizing international communication …

STUDY QUESTION: To what extent is male physical activity (PA) associated with fecundability (per-cycle probability of conception)? SUMMARY ANSWER: Preconception levels of vigorous, moderate, or total PA were not consistently associated wit…

STUDY QUESTION: What is the association between infertility with or without fertility treatment and incident onset of systemic autoimmune rheumatic disease (SARD) among women who give birth? SUMMARY ANSWER: Women who experienced infertilit…

STUDY QUESTION: Is the probability of pregnancy different between women using biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART? SUMMARY ANSWER: Meta-analysis of eight randomized clinical trials (RCTs) su…

STUDY QUESTION: How does two-consecutive single embryo transfer (2xSET) affect reproductive outcomes of IVF and ICSI compared to double embryo transfer (DET)? SUMMARY ANSWER: Two-consecutive SET may provide greater or comparable live birth…

STUDY QUESTION: Which research topics in the area of infertility should be prioritized in the allocation of research resources? SUMMARY ANSWER: Twelve research priorities were formulated, spanning the following areas: preventing infertilit…

STUDY QUESTION: Does definitive occlusion of uterine arteries have a short- or long-term impact on ovarian reserve markers in reproductive-age women undergoing laparoscopic myomectomy? SUMMARY ANSWER: Preventive definitive uterine artery o…

STUDY QUESTION: What is the incidence of and risk factors for monozygotic twinning (MZT) following single embryo transfer (SET) in ART cycles in Australia and New Zealand? SUMMARY ANSWER: MZT occurred in 1.5% of live births following SET, …

STUDY QUESTION: What number of oocytes retrieved is associated with the highest cumulative live birth rates (CLBRs) in the fresh and subsequent frozen cycles following ovarian stimulation with follitropin delta? SUMMARY ANSWER: The CLBR in…