Biophysical journal

2025

Estrogen attenuates stiffness-driven fibrotic signaling via transcriptional regulation.

doi:10.1016/j.bpj.2025.05.007 ·PMID:40364520

Fibrosis, marked by excessive extracellular matrix (ECM) accumulation, underlies functional decline in numerous diseases and often presents with sex-specific differences in severity. Although biochemical pathways have been widely studied, t…

2014

Autocrine A2 in the T-system of ventricular myocytes creates transmural gradients in ion transport: a mechanism to match contraction with load?

doi:10.1016/j.bpj.2014.04.042 ·PMID:24896115

Transmural heterogeneities in Na/K pump current (IP), transient outward K(+)-current (Ito), and Ca(2+)-current (ICaL) play an important role in regulating electrical and contractile activities in the ventricular myocardium. Prior studies in…

2005

Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle.

doi:10.1529/biophysj.105.062406 ·PMID:16127169

There are well-documented differences in ion channel activity and action potential shape between epicardial (EPI), midmyocardial (MID), and endocardial (ENDO) ventricular myocytes. The purpose of this study was to determine if differences e…