PloS one

BackgroundCryopreservation and warming can induce cellular stress that impairs oocyte and embryo competence, particularly in poor-prognosis patients. Although fatty acids and melatonin have been proposed to support cytoskeletal stability an…

This study explored the genetic evidence linking triglyceride-related pathways and lipid-lowering drug targets with endometriosis risk and investigated the genetic association between TG levels and EM. Using genome-wide association study (G…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease characterized by ectopic endometrial growth. This study aimed to identify and analyze potential signatures of pyroptosis-related genes in EMs. METHODS: We conducted a compre…

BackgroundHysterectomy is a commonly performed gynecologic procedure; however, evidence regarding how different surgical techniques affect postoperative vaginal anatomy and sexual function remains inconsistent. This study aimed to evaluate …

ObjectiveTo evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea.MethodsA total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy administere…

BackgroundPersistent autonomic dysfunction disrupts homeostasis and promotes pathological processes underlying several major chronic conditions including cancer and cardiovascular disease. Little is known about the lived experience of indiv…

BackgroundMenstruation can be accompanied by stressful experiences and one such experience is the abnormal menstrual cycle, which could include menstrual irregularity and painful menstruation. Menstrual irregularity is defined as deviations…

BackgroundGynecological conditions are common among premenopausal women and significantly affect fertility, quality of life, and productivity. Magnetic Resonance Imaging (MRI) offers superior soft tissue characterization compared to other m…

A quality improvement project was implemented at a single medical center's outpatient benign gynecological surgery division to address prolonged post anesthesia care unit (PACU) stays (defined as greater than 120 minutes). Initial barrier a…

Non-communicable diseases (NCDs) account for more than 81% of all deaths in Iran and impose a substantial burden on the national health system. Although Iran has implemented multiple initiatives, including the World Health Organization's ST…

BackgroundRed blood cell volume distribution width (RDW) and albumin have been increasingly recognized for their roles in inflammatory diseases. However, the relationship between RDW-to-albumin ratio (RAR) and acute kidney injury (AKI) in a…

BACKGROUND: Drug-drug interactions (DDIs) represent a major preventable cause of medication-related harm globally. Their prevalence varies across health systems, but common drivers include polypharmacy, aging populations, and specialty-spec…

BackgroundPremenstrual syndrome (PMS) is common among women of reproductive age and may impair quality of life, academic performance, and social functioning. In Lebanon, data on PMS and its management among female university students remain…

This study examined psychophysiological responses to stride frequency manipulation during walking in men and women. Nineteen healthy adults (11 men, 8 women) completed two sessions: familiarization session (session 1) during which the prefe…

INTRODUCTION: The objective of this study was to investigate alleviation of adenomyosis symptoms after microwave ablation (MWA) and uterine artery embolization (UAE) in a small pilot study. MATERIAL AND METHODS: 20 premenopausal women with…

BackgroundChronic diabetic wounds are often complicated by biofilm-forming, antibiotic-resistant pathogens such as Staphylococcus aureus and Acinetobacter baumannii, which delay healing. This study evaluated the synergistic effects of genta…

IntroductionHuman sexuality is an important aspect of functionality, and many patients believe that it determines their quality of life. Sexual dysfunction can lead to stress, strained relationships, and a decrease in self-esteem. The major…

BACKGROUND: A link exists between decorin (DCN) and endometriosis, nevertheless, the role of DCN in this condition remains unclear. This study aims to bioinformatically characterize DCN expression, diagnostic value, and related signaling in…

ObjectiveTo assess the feasibility of using a virtual reality medical hypnosis (VRH) device for anxiolytic purposes during frozen embryo transfer (FET) and to observe its effect on subsequent pregnancy rate.DesignThis is a prospective, sing…

Anal fistula is a complex and often prolonged condition that significantly impacts patients' daily lives and psychological well-being. This qualitative study explored how individuals living with anal fistula experience stigma, disruption, a…

BACKGROUND: Increased uterine artery resistance in pregnant women with a history of cesarean section has been suggested to contribute to adverse pregnancy outcomes. However, the literature presents conflicting reports on this association. I…

BACKGROUND: Long-acting Gonadotropin-releasing hormone analogs(GnRHa), including leuprolide, goserelin, histrelin, buserelin, triptorelin, have been widely used for a variety of diseases including prostate cancer, breast cancer, endometrios…

Understanding how ageing impacts endometrial function is crucial for preserving fertility in older females. While ageing-related cellular dysfunction and inflammation are observed in the bovine uterus, its effects on endometrial physiology …

Conventional expression studies quantify messenger RNA (mRNA) transcript levels gene-by-gene. We recently showed that protein expression is modulated at a global scale by amino acid availability, suggesting that mRNA expression levels might…