Journal of molecular and cellular cardiology

2018

Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy.

doi:10.1016/j.yjmcc.2017.12.008 ·PMID:29275006

AimDuchenne Muscular Dystrophy (DMD) is associated with progressive depressed left ventricular (LV) function. However, DMD effects on myofilament structure and function are poorly understood. Golden Retriever Muscular Dystrophy (GRMD) is a …

2017

Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization.

doi:10.1016/j.yjmcc.2017.06.014 ·PMID:28668303

The role of Ca2+-activated Cl- current (ICl(Ca)) in cardiac arrhythmias is still controversial. It can generate delayed afterdepolarizations in Ca2+-overloaded cells while in other studies incidence of early afterdepolarization (EAD) was re…

2009

NFATc3-dependent loss of I(to) gradient across the left ventricular wall during chronic beta adrenergic stimulation.

doi:10.1016/j.yjmcc.2008.10.016 ·PMID:19027024

In heart, pore-forming Kv4 alpha channel subunits underlie the K(+) transient outward current (I(to)). Expression of Kv4 is greater in left ventricular epicardial (EPI) than in endocardial (ENDO) cells, resulting in larger I(to) in EPI than…