Journal of molecular and cellular cardiology

lab-animal 2018

Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy

doi:10.1016/j.yjmcc.2017.12.008 ·PMID:29275006

AIM: Duchenne Muscular Dystrophy (DMD) is associated with progressive depressed left ventricular (LV) function. However, DMD effects on myofilament structure and function are poorly understood. Golden Retriever Muscular Dystrophy (GRMD) is …

lab-animal 2017

Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization.

doi:10.1016/j.yjmcc.2017.06.014 ·PMID:28668303

The role of Ca2+-activated Cl- current (ICl(Ca)) in cardiac arrhythmias is still controversial. It can generate delayed afterdepolarizations in Ca2+-overloaded cells while in other studies incidence of early afterdepolarization (EAD) was re…

lab-animal 2009

NFATc3-dependent loss of I(to) gradient across the left ventricular wall during chronic beta adrenergic stimulation

doi:10.1016/j.yjmcc.2008.10.016 ·PMID:19027024

In heart, pore-forming Kv4 alpha channel subunits underlie the K(+) transient outward current (I(to)). Expression of Kv4 is greater in left ventricular epicardial (EPI) than in endocardial (ENDO) cells, resulting in larger I(to) in EPI than…