Basic and clinical andrology

2026

A case of secretory azoospermia: is valganciclovir responsible?

doi:10.1186/s12610-026-00299-0 ·PMID:42410506

BackgroundValganciclovir, the prodrug of ganciclovir, is an antiviral agent targeting herpes viruses. It is indicated for the prophylaxis or treatment of cytomegalovirus infections in immunocompromised patients. Pre-clinical studies state g…

2026

Association of sperm DNA fragmentation index with semen quality and ART outcomes: real-world evidence from a retrospective cohort.

doi:10.1186/s12610-026-00308-2 ·PMID:41862805

BACKGROUND: Sperm DNA fragmentation index (DFI) has emerged as a potential marker of male fertility, but its clinical value in assisted reproductive technology (ART) remains debated. This study aimed to investigate the association between s…

2025

Density gradient centrifugation specifically improves sperm motility in hyperuricemia: evidence from intrauterine insemination cycles - retrospective cohort study.

doi:10.1186/s12610-025-00292-z ·PMID:41204074

BackgroundHyperuricemia (HUA) impairs sperm function via oxidative stress and metabolic dysregulation. This retrospective cohort study aimed to investigate the therapeutic effect of density gradient centrifugation (DGC) on HUA-associated sp…

2023

Effects of alcohol use on sperm chromatin structure, a retrospective analysis.

doi:10.1186/s12610-023-00189-9 ·PMID:37286947

BackgroundThe evaluation of the infertile couple is often complex as multiple factors in both the male and female can contribute, including social history. Previous studies have displayed that male ethanol consumption can disturb sperm moti…

2021

D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study.

doi:10.1186/s12610-021-00131-x ·PMID:34078260

BackgroundAndrogen deficiency affects men in the adulthood, causing several harmful effects at the reproductive and behavioural levels. Since aromatase is an enzyme that catalyses the conversion of androgens to estrogens, and it is responsi…

2018

Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study.

doi:10.1186/s12610-018-0070-6 ·PMID:29619224

BackgroundRecurrent pregnancy loss (RPL) is defined as the loss of at least three pregnancies in the first trimester. Although the most common cause is embryo aneuploidy, and despite female checkup and couple karyotyping, in about 50% of ca…

2017

"This is where it all started" - the pivotal role of PLCζ within the sophisticated process of mammalian reproduction: a systemic review.

doi:10.1186/s12610-017-0054-y ·PMID:28533904

Mammalian reproduction is one of the most complex and fascinating biological phenomenon, which aims to transfer maternal and paternal genetic material to the next generation. At the end of oogenesis and spermatogenesis, both haploid gametes…

2016

Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials.

doi:10.1186/s12610-016-0042-7 ·PMID:27895921

BackgroundThe human papilloma virus (HPV) infections were addressed with two FDA-approved HPV vaccines: quadrivalent and bivalent vaccine. The objective of this manuscript is to determine the safety of the HPV vaccine.ResultsA search of Pub…

2013

In Vitro fertilization failure of normozoospermic men: search for a lack of testicular isozyme of angiotensin-converting enzyme.

doi:10.1186/2051-4190-23-4 ·PMID:25780568

BackgroundAngiotensin converting enzyme (ACE) is a metalloprotease with two isoforms. The somatic isoform is a key component of the renin-angiotensin system; its main function is to hydrolyse angiotensin I into angiotensin II. The germinal …