Genes & development

· 3 papers in corpus
2025
Analysis of knockout mice reveals critical female-specific roles for the Hippo pathway component PTPN14.
doi:10.1101/gad.352620.125 ·PMID:40533389

The Hippo pathway regulates many physiological processes, including development, tumor suppression, and wound healing. One understudied Hippo pathway component is PTPN14, an evolutionarily conserved tyrosine phosphatase that inhibits YAP/TA…

2019
The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration.
doi:10.1101/gad.320523.118 ·PMID:30923168

Transcription factors (TFs) are dosage-sensitive master regulators of gene expression, with haploinsufficiency frequently leading to life-threatening disease. Numerous mechanisms have evolved to tightly regulate the expression and activity …

2018
Molecular mechanisms of the preventable causes of cancer in the United States.
doi:10.1101/gad.314849.118 ·PMID:29945886

Annually, there are 1.6 million new cases of cancer and nearly 600,000 cancer deaths in the United States alone. The public health burden associated with these numbers has motivated enormous research efforts into understanding the root caus…