iScience

iScience · ISSN (e) 2589-0042 · 78 papers in corpus
other 2020
Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) Heteromeric Complexes Promote Human Ovarian Follicle Survival
doi:10.1016/j.isci.2020.101812 ·PMID:33299978

Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation. However, contradicting in vitro data suggest a different view on physiological significance…

lab-animal 2019
Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation
doi:10.1016/j.isci.2019.09.006 ·PMID:31557715

We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter a…

lab-animal 2019
The Ancestral Environment Shapes Antiviral CD8+ T cell Responses across Generations
doi:10.1016/j.isci.2019.09.014 ·PMID:31569050

Recent studies have linked health fates of children to environmental exposures of their great grandparents. However, few studies have considered whether ancestral exposures influence immune function across generations. Here, we report trans…