PLoS neglected tropical diseases

· 5 papers in corpus
2025
Schistosoma haematobium infection is associated with oncogenic gene expression in Cervical Mucosa, with enhanced effects following treatment: A pilot study.
doi:10.1371/journal.pntd.0013569 ·PMID:41270010

BackgroundSchistosoma haematobium is a parasitic worm that infects over 110 million people worldwide, laying eggs that migrate into host urinary and reproductive tracts. While S. haematobium is a known carcinogen in the urinary bladder, its…

2023
Cost-effectiveness of human T-cell leukemia virus type 1 (HTLV-1) antenatal screening for prevention of mother-to-child transmission.
doi:10.1371/journal.pntd.0011129 ·PMID:36809372

BackgroundHuman T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy-tropical spastic paraparesis (HAM/TSP) with a poor prognosis. This study aimed to evaluate the cost-effective…

2022
Absence of lower genital tract lesions among women of reproductive age infected with Schistosoma mansoni: A cross-sectional study using a colposcope in Western Kenya.
doi:10.1371/journal.pntd.0010473 ·PMID:35802746

BackgroundFemale genital schistosomiasis (FGS) constitutes four different lesions known to be caused by Schistosoma haematobium ova deposited in the genital tract. Schistosoma mansoni ova may also be found in the genital tract. However, it …

2014
A new mouse model for female genital schistosomiasis.
doi:10.1371/journal.pntd.0002825 ·PMID:24786606

BackgroundOver 112 million people worldwide are infected with Schistosoma haematobium, one of the most prevalent schistosome species affecting humans. Female genital schistosomiasis (FGS) occurs when S. haematobium eggs are deposited into t…

2012
Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease.
doi:10.1371/journal.pntd.0001681 ·PMID:22679524

BackgroundInfection with Wuchereria bancrofti can cause severe disease characterized by subcutaneous fibrosis and extracellular matrix remodeling. Matrix metalloproteinases (MMPs) are a family of enzymes governing extracellular remodeling b…