BMC cancer

BACKGROUND: Endometriosis is associated with an increased risk of type I ovarian cancer, yet the prognostic relevance of concurrent endometriosis at diagnosis remains unclear. This cohort study evaluated whether endometriosis independently …

PURPOSE: The COVID-19 pandemic posed substantial challenges to cancer care, raising concerns about the safety of ongoing endocrine therapy in women with breast cancer. However, real-world evidence on the association between endocrine therap…

BACKGROUND: Serum cancer antigen 125 (CA-125) is widely used in the diagnosis and follow-up of ovarian cancer, but its reference interval may vary between populations. We aimed to establish sex- and age-specific reference intervals for seru…

BACKGROUND: Ovarian cancer is one of the most common gynaecological cancers affecting more than 300,000 women worldwide each year. S100 calcium-binding protein A6 (S100A6) is a member of the S100 family of calcium-binding proteins. Upon act…

ObjectiveGallbladder cancer (GBC) is a rare gastrointestinal malignancy with a global 5-year survival rate of less than 5%. Early diagnosis is challenging owing to the lack of specific clinical symptoms. Additionally, the high heterogeneity…

BACKGROUND: Optimal cytoreductive surgery and platinum sensitivity are critical prognostic factors in advanced epithelial ovarian cancer (EOC). However, the preoperative value of routinely available serum biomarkers in predicting surgical o…

BACKGROUND: Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare uterine tumors predominantly made up of sex cord-like elements. However, sex cord-like elements are also concomitant components in a variety of non-UTROSCTs, …

BACKGROUND: Numerous studies have explored the histological overlap between endometrial carcinoma and adenomyosis, yet the clinical implications of their co-occurrence remain ambiguous. This study aims to evaluate the impact of adenomyosis …

OBJECTIVE: Although struma ovarii (SO) is mostly benign, it is frequently overtreated due to challenges in differentiating it from malignant tumors. Therefore, the purpose of this study was to investigate the clinical, laboratory, ultrasono…

BACKGROUND: Gynecological cancers (GCs) affect the reproductive system of females, and are of multiple types depending on the affected organ most common of which are cervical, endometrial, ovarian cancers. Among different risk factors for G…

BACKGROUND: As the precursor malignancy of endometrial cancer (EC), about 50% of endometrial complex atypical hyperplasia (CAH) will eventually progress to EC. Elucidating the underlying transformation mechanisms could aid in disease manage…

BACKGROUND: This study aimed to evaluate the effectiveness of different tracers´ application techniques for sentinel lymph node (SLN) detection in women with endometrial cancer undergoing laparotomy. Additionally, potential risk factors for…

BACKGROUND: The plasma concentration of endoxifen, the active metabolite of tamoxifen, might be affected by different CYP2D6 genotypes in patients with breast cancer, but solid evidence is still lacking in Asian patients. This prospective s…

BACKGROUND: The vaccine-mediated therapy is one interesting option to treat lung cancer. This research introduces a novel therapeutic vaccine based on nanoliposomes containing multi-epitopes of MAGE-A3, TGF-β2, and VEGF-A to enhance immune …

OBJECTIVES: To evaluate the efficacy and safety of ultrasound-guided percutaneous thermal ablation for abdominal wall metastases. MATERIALS & METHODS: We retrospectively analyzed patients with abdominal wall metastatic nodules who underwen…

BACKGROUND: The impact of the presence of adenomyosis on survival in patients with non-endometrioid endometrial cancer (EC) remains unclear. The aim of this study is to compare the effect of the presence or absence of histologically proven …

BACKGROUND: To distinguish and co-detect aneuploid CD31- tumor cells (TCs) and CD31+ tumor endothelial cells (TECs) may have significant diagnostic values for cervical cancer screening. However, there are very few relevant studies. In the p…

INTRODUCTION: Ovarian cancer significantly contributes to cancer-related deaths among women. Resistance to anchorage-dependent cell death (anoikis) plays a vital role in facilitating metastasis and worsening patient prognosis. Recent develo…

BACKGROUND: To assess the utility of the TCGA molecular classification of endometrial cancer in a well-annotated, moderately sized, consecutive cohort of Chinese patients with ovarian clear cell carcinoma (OCCC). METHODS: We performed DNA …

OBJECTIVE: This study aimed to analyze the trends and epidemiological characteristics of pancreatic cancer (PC) mortality in China from 2004 to 2021, focusing on gender, age, and regional disparities. The goal was to provide a comprehensive…

BACKGROUND: With recent evidence that opportunistic salpingectomy is effective in preventing high grade serous carcinoma, it is imperative to consider the optimal use of this procedure. In this research, we investigated the opinions of obst…

BACKGROUND: Aberrant changes in protein phosphorylation are a hallmark of cancer, often leading to hyperactivation of signalling pathways such as the mitogen activated protein kinase (MAPK) pathway. Although kinase inhibitors are successful…

BACKGROUND: The diagnosis of rare uterine leiomyosarcoma (uLMS) remains a challenge given the high incidence rates of benign uterine tumors such as leiomyoma (LM). In the last decade, several clinical scores and blood serum markers have bee…

BACKGROUND: Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it…

BACKGROUND: The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate. Hence, the objective of this study is to ev…