Molecular psychiatry

2026

A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.

doi:10.1038/s41380-025-03392-4 ·PMID:41420111

Migraine is a neurovascular disorder that poses a high burden to Veterans, who face a greater risk than sex-matched individuals in the general population. Genetic research on migraine in Veterans and its link to psychiatric comorbidities is…

2025

Three cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment.

doi:10.1038/s41380-024-02750-y ·PMID:39304742

Immunological aetiology is supported for a subgroup with obsessive compulsive disorder (OCD) and conceptualized as autoimmune OCD. The longitudinal clinical course is detailed for three severely ill cases with OCD and indications of immunol…

2024

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.

doi:10.1038/s41380-024-02446-3 ·PMID:38355787

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding…