Cancer chemotherapy and pharmacology

· 2 papers in corpus

lab-animal 2024

Bidirectional pharmacokinetic drug interactions between olaparib and metformin

doi:10.1007/s00280-023-04591-y ·PMID:37815561

OBJECTIVE: Olaparib is a PARP (poly-ADP-ribose polymerase) inhibitor used for maintenance therapy in BRCA-mutated cancers. Metformin is a first-choice drug used in the treatment of type 2 diabetes. Both drugs are commonly co-administered to…

nonrandomized-trial 2009

Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics

doi:10.1007/s00280-009-1038-1 ·PMID:19479252

PURPOSE: GnRH analogs are useful for the treatment of prostate cancer, but require parenteral administration. The peptide GnRH antagonist acyline potently suppresses luteinizing hormone (LH) and testosterone in man; however, its clinical ut…