Cellular oncology (Dordrecht, Netherlands)

2025

Novel insights into lncRNAs as key regulators of post-translational modifications in cancer: mechanisms and therapeutic potential.

doi:10.1007/s13402-025-01086-1 ·PMID:40601247

Abnormal post-translational modifications (PTMs) play a crucial role in tumor initiation and progression. However, the mechanisms by which lncRNAs, as emerging epigenetic regulators, mediate PTMs remain largely unexplored. This review provi…

2019

Tumor-associated macrophages: role in cancer development and therapeutic implications.

doi:10.1007/s13402-019-00453-z ·PMID:31144271

BackgroundTumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting …

2017

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer.

doi:10.1007/s13402-016-0309-1 ·PMID:27981507

BackgroundIn spite of various treatment options currently available, ovarian cancer (OC) still remains a leading cause of death in women world-wide. Diagnosis at an early stage is one of the most important factors that determines survival. …

2016

Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-β.

doi:10.1007/s13402-015-0257-1 ·PMID:26584547

PurposeLoss of a cytostatic response to TGF-β has been implicated in multiple hyper-proliferative disorders, including cancer. Although several key genes involved in the cytostatic activity of TGF-β have in the past been identified, its exa…

2016

Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor.

doi:10.1007/s13402-015-0263-3 ·PMID:26701791

BackgroundIGF1 is a key regulator of tissue growth and development and has been implicated in the initiation and progression of various cancers, including breast cancer. Through IGF1 mRNA splicing different precursor pro-peptides, i.e., the…