Frontiers in endocrinology

BACKGROUND: Compared with overnight insemination, it remains uncertain whether short-term insemination can improve outcomes in poor responders, and few studies have used cumulative live birth rate as the primary endpoint. The study aims to …

BACKGROUND: Endometrial dysfunction in women with polycystic ovary syndrome (PCOS) significantly contributes to adverse pregnancy outcomes, including recurrent implantation failure and high miscarriage rates. However, the specific roles of …

BACKGROUND: Implantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful impla…

AIMS: To evaluate DuoStim strategy across a decade from its clinical implementation in IVF by comparing embryological and clinical outcomes between the first and second ovarian stimulations (1st-OS and 2nd-OS) conducted within 30 days, focu…

OBJECTIVE: To evaluate the predictive value of endometrial and uterine artery blood flow parameters, combined with clinical indicators, for embryo implantation outcomes in PCOS patients undergoing IVF-ET across different BMI categories. ME…

Short-term IVF (S-IVF) is a fertilization approach to co-incubate the sperm and oocyte for a short duration and denude the cumulus cells afterwards. The S-IVF combined with early rescue intracytoplasmic sperm injection (ICSI) strategy can r…

BACKGROUND: The clinical efficacy of antioxidants in assisted reproductive technology (ART) remains inconsistent. This systematic review and meta-analysis aimed to evaluate the impact of oral antioxidant supplementation on reproductive outc…

Endometriosis is a debilitating chronic inflammatory disorder driven by extensive molecular reprogramming. Despite significant bench research into its pathogenesis, translating these molecular discoveries into clinical practices that improv…

BACKGROUND: Estrogens have been proposed as modulators of gut microbiome (GM) composition, yet evidence from observational studies remains inconsistent. OBJECTIVE: This meta-analysis aimed to systematically summarise existing evidence on G…

PURPOSE: To investigate the impact of regressed endometrial hyperplasia (EH) on assisted reproductive technology outcomes, particularly in comparison with infertile women with a relatively normal endometrium. METHODS: This retrospective st…

BACKGROUND AND AIMS: Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, an…

Endometriosis, a chronic inflammatory disease affecting 10-15% of women of reproductive age, remains a leading cause of female subfertility. While current management strategies focus on surgical excision and hormonal suppression, these appr…

INTRODUCTION: Adenomyosis is a uterine disorder defined by presence of endometrial glands and stroma within the myometrium with surrounding myometrial hyperplasia. Research has shown that ultrasound (US) can play a key role in early adenomy…

IntroductionWhether the total gonadotropin (Gn) dose used for controlled ovarian stimulation is independently associated with live birth and embryo quality remains controversial, largely because the dose is individualized according to patie…

Whether embryo morphokinetic quality influences the clinical efficacy of different embryo transfer (ET) strategies in good prognosis ICSI/IVF cycles remains an open question. This study evaluated the impact of early morphokinetic selection …

INTRODUCTION: Hydrosalpinx is one of the common organic causes of infertility, and the accumulation of fluid in this condition can severely affect embryo implantation and development. MATERIAL AND METHODS: We collected fallopian tube fluid…

PURPOSE: To compare uterine ultrasound measurements in women with normogonadotropic anovulation, specifically those with polycystic ovary syndrome (PCOS) and hypothalamic-pituitary-ovarian dysfunction (HPOD), with those of regularly menstru…

RESEARCH QUESTION: Do embryo parameters and live birth rates differ between patients with endometrioma undergoing a freeze-all strategy using either GnRH antagonists or progestin-primed ovarian stimulation (PPOS)? DESIGN: This retrospectiv…

BACKGROUND AND OBJECTIVE: Ovarian endometriosis (OE), characterized by endometriotic cysts, adversely affects ovarian function and comprises in vitro fertilization and embryo transfer (IVF-ET) outcomes. Acupoint application therapy (AAT), w…

BACKGROUND: Infertility rates have been rising globally, necessitating accurate assessment tools for ovarian reserve. Anti-Müllerian hormone (AMH) is a key biomarker for evaluating ovarian reserve, yet age-stratified reference data remain l…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common cause of irregular menstrual cycles and infertility. Current treatments primarily involve ovulation induction and sex steroid hormone therapy. Tokishakuyakusan (TSS) is a traditional …

BACKGROUND: There is limited research about the pregnancy outcomes of POSEIDON group 2 patients. This study aims to evaluate the factors related to the clinical outcomes of in vitro fertilization (IVF) and/or intracytoplasmic sperm injectio…

OBJECTIVE: To identify the determinants influencing clinical pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. METHODS: A retrospective analysis was conducted on patients who underwent FET at the Department of Reproductive …

PURPOSE: This study aims to assess the impact of ultrasound parameters on endometrial receptivity in patients undergoing IVF-ET and to establish a predictive model for ongoing pregnancy outcomes. METHODS: The prospective cohort study inclu…

PURPOSE: To investigate the dynamic changes of serum Anti-Müllerian Hormone (AMH) and Inhibin B (INHB) during controlled ovarian hyperstimulation (COH) in patients with polycystic ovarian syndrome (PCOS) and analyze their correlation with C…