Prostaglandins & other lipid mediators

review 2023

COX isozymes and non-uniform neoangiogenesis: What is their role in endometriosis?

doi:10.1016/j.prostaglandins.2023.106734 ·PMID:37028470

This literature review compared the efficacy in of NSAIDs with a placebo in pain relief and disease regression of endometriosis. Despite the poor evidence found, the results showed that NSAIDs were more effective in pain relief with regress…

article 2020

Lipoxin A4 inhibits the development of endometriosis in a mouse model by suppressing local estradiol synthesis

doi:10.1016/j.prostaglandins.2020.106521 ·PMID:33279654

We investigated whether lipoxin A4 (LXA4) inhibits the development of endometriosis by suppressing local estradiol synthesis. An endometriosis mouse model was constructed by surgical transplantation to subcutanous tissue sites. The treatmen…

2018

Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.

doi:10.1016/j.prostaglandins.2017.11.001 ·PMID:29129796

Prostaglandins are formed by enzymatic and non-enzymatic mechanisms. They have been detected in human ovarian follicular fluid (HFF), a medium rich in growth factors and nutrients important for oocyte growth and fertility. However, the comp…

2017

Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.

doi:10.1016/j.prostaglandins.2017.05.003 ·PMID:28549801

BackgroundColorectal cancer (CRC) is the most common cancer. A proper method to reduce mortality of CRC is chemoprevention to prevent initiation and promotion of intestinal tumorgenesis. One of the promising and developing chemopreventive a…