Biology direct

· 4 papers in corpus
2026
O-GlcNAcylation regulates endometrial decidualization through dual mechanisms: PI3K-AKT axis-mediated phosphorylation and direct modification of FOXO1.
doi:10.1186/s13062-026-00750-2 ·PMID:41821103

BackgroundSteroid hormone-driven endometrial decidualization involves the differentiation of endometrial stromal cells into decidual cells, which form the decidua for blastocyst implantation. This process is a prerequisite for successful em…

2024
LncRNA NORFA promotes the synthesis of estradiol and inhibits the apoptosis of sow ovarian granulosa cells through SF-1/CYP11A1 axis.
doi:10.1186/s13062-024-00563-1 ·PMID:39523350

BackgroundBiosynthesis of 17β-estradiol (E2) is a crucial ovarian function in mammals, which is essential for follicular development and pregnancy outcome. Exploring the epigenetic regulation of E2 synthesis is beneficial for maintaining ov…

2024
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice.
doi:10.1186/s13062-024-00496-9 ·PMID:38956667

BackgroundAdiposity profoundly impacts reproductive health in both humans and animals. However, the precise subpopulations contributing to infertility under obese conditions remain elusive.ResultsIn this study, we established an obese mouse…

2023
Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models.
doi:10.1186/s13062-023-00380-y ·PMID:37165439

ObjectiveHypertriglyceridemia (HTG) is one of the common causes of acute pancreatitis (AP). Hyperlipidemic acute pancreatitis (HTG-AP) is associated with higher mortality owing to its tendency for greater severity and rapid progression. The…