BMC pharmacology

· 1 paper in corpus
2008
RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice.
doi:10.1186/1471-2210-8-7 ·PMID:18474108

BackgroundGlucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory response, and concerns over this exacerbation have limited the…