Genes & cancer

· 3 papers in corpus
2024
Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction.
doi:10.18632/genesandcancer.237 ·PMID:39132498

BackgroundIn some breast cancers, altered estrogen-sulfotransferase (SULT1E1) and its inactivation by oxidative-stress modifies E2 levels. Parallelly, hypoxia-inducible tissue-damaging factors (HIF1α) are induced. The proteins/genes express…

2018
Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques.
doi:10.18632/genesandcancer.170 ·PMID:30108684

Colorectal cancer accounts for a substantial number of deaths each year worldwide. Lynch Syndrome is a genetic form of colorectal cancer (CRC) caused by inherited mutations in DNA mismatch repair (MMR) genes. Although researchers have devel…

2013
Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers.
doi:10.1177/1947601913486344 ·PMID:23946868

The human GT198 gene (gene symbol PSMC3IP) is located at chromosome 17q21, 470 kb proximal to BRCA1, a locus previously linked to breast and ovarian cancer predisposition. Its protein product (also known as TBPIP and Hop2) has been shown to…