Journal of the American College of Cardiology

2023

Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review.

doi:10.1016/j.jacc.2023.06.045 ·PMID:37730292

Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary athe…

2022

Infertility and Risk of Heart Failure in the Women's Health Initiative.

doi:10.1016/j.jacc.2022.02.020 ·PMID:35450577

BackgroundThere is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk…

2017

Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series.

doi:10.1016/j.jacc.2017.05.034 ·PMID:28683968

The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human biology. However, when ROS generation exceeds endogenous antioxidant capacity, oxidative stress arises. If unchecked, ROS production and oxidative stres…

2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

doi:10.1016/j.jacc.2016.11.056 ·PMID:28209224

BackgroundGenome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits.ObjectivesThis st…