Cancer cell — Endo Lab

2023

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps.

doi:10.1016/j.ccell.2023.02.001 ·PMID:36827980

Neutrophils are major effectors and regulators of the immune system. They play critical roles not only in the eradication of pathogens but also in cancer initiation and progression. Conversely, the presence of cancer affects neutrophil acti…

2023

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.

doi:10.1016/j.ccell.2023.03.002 ·PMID:36963401

ARID1A, encoding a subunit of the SWI/SNF complex, is mutated in ∼50% of clear cell ovarian carcinoma (OCCC) cases. Here we show that inhibition of the mevalonate pathway synergizes with immune checkpoint blockade (ICB) by driving inflammas…

2014

Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.

doi:10.1016/j.ccell.2014.08.017 ·PMID:25284480

PIK3R1 (p85α regulatory subunit of PI3K) is frequently mutated across cancer lineages. Herein, we demonstrate that the most common recurrent PIK3R1 mutation PIK3R1(R348∗) and a nearby mutation PIK3R1(L370fs), in contrast to wild-type and mu…