Molecular immunology

article 2026

Luteolin inhibits IL-33/ST2L-induced M2 macrophage polarization in endometriosis

doi:10.1016/j.molimm.2026.05.008 ·PMID:42167049

BACKGROUND: Endometriosis is a chronic inflammatory disease characterized by immune microenvironment dysregulation, with the IL-33/ST2L signaling axis playing a crucial role in macrophage polarization and disease progression. Despite growin…

article 2023

Differential expression of interleukin-35 receptor distinguishes different subsets of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in a mouse endometriosis model

doi:10.1016/j.molimm.2023.10.011 ·PMID:37944204

The immune system contributes to the pathophysiology of endometriosis. The role of ThGM cells, which produce granulocyte macrophage-colony-stimulating factor (GM-CSF), in the pathogenesis of endometriosis remains unknown. To analyze the fea…

2015

Mast cells: versatile gatekeepers of pain.

doi:10.1016/j.molimm.2014.03.001 ·PMID:24666768

Mast cells are important first responders in protective pain responses that provoke withdrawal from intense, noxious environmental stimuli, in part because of their sentinel location in tissue-environment interfaces. In chronic pain disorde…

article 2009

ERB-041, a selective ERβ agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-κB activation

doi:10.1016/j.molimm.2009.04.014 ·PMID:19447495

ObjectiveThe aim of the present study was to assess the anti-inflammatory effects of selective ER beta (ER beta) agonist on lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) production in peritoneal macrophages (PMs) o…