Genes and immunity

Genes Immun · ISSN (e) 1476-5470 · 3 papers in corpus
other 2026
CD11d+ NK cell-derived exosomal HSPB1 suppresses angiogenesis in adenomyosis
doi:10.1038/s41435-026-00379-1 ·PMID:41760944

Our study aimed to explore the mechanisms underlying abnormal angiogenesis in adenomyosis (AM). Endometria of internal adenomyosis (AM-in) and external adenomyosis (AM-ex) were collected for single-cell RNA-sequencing. Cells showing consist…

2020
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.
doi:10.1038/s41435-020-0096-6 ·PMID:32203088

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone.…

2012
Synovial expression of Th17-related and cancer-associated genes is regulated by the arthritis severity locus Cia10.
doi:10.1038/gene.2011.73 ·PMID:22048456

We have previously identified Cia10 as an arthritis severity and articular damage quantitative trait locus. In this study, we used Illumina RatRef-12 microarrays to analyze the expression of 21,922 genes in synovial tissues from arthritis-s…